Hedgehog signaling through GLI1 and GLI2 is required for epithelial-mesenchymal transition in human trophoblasts

Tang Chao; Mei Liu; Pan Liyu; Xiong Wenyi; Zhu Haibin; Ruan Hongfeng; Zou Chaochun; Tang Lanfang; Iguchi Takuma; Wu Ximei

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Hedgehog signaling through GLI1 and GLI2 is required for epithelial-mesenchymal transition in human trophoblasts

機譯：滋養細胞上皮-間質轉化需要通過GLI1和GLI2的刺猬信號

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Background: Epithelial to mesenchymal transition (EMT) is critical for human placental development, trophoblastic differentiation, and pregnancy-associated diseases. Here, we investigated the effects of hedgehog (HH) signaling on EMT in human trophoblasts, and further explored the underlying mechanism.

機譯：背景：上皮向間質轉化（EMT）對于人類胎盤發育，滋養細胞分化和妊娠相關疾病至關重要。在這里，我們調查了刺猬（HH）信號對人類滋養細胞EMT的影響，并進一步探討了其潛在機制。

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來源
《Biochimica et Biophysica Acta. General Subjects》 |2015年第7期|共11頁
作者
Tang Chao; Mei Liu; Pan Liyu; Xiong Wenyi; Zhu Haibin; Ruan Hongfeng; Zou Chaochun; Tang Lanfang; Iguchi Takuma; Wu Ximei;
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正文語種 eng
中圖分類 Q5;
關鍵詞
Hedgehog signaling; Trophoblast; Epithelial-mesenchymal transition;

機譯：刺猬信號;滋養細胞;上皮-間質轉化;
入庫時間 2022-08-18 09:01:40

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1. Hedgehog signaling through GLI1 and GLI2 is required for epithelial-mesenchymal transition in human trophoblasts [J] . Tang Chao, Mei Liu, Pan Liyu, Biochimica et Biophysica Acta. General Subjects . 2015,第7期

機譯：滋養細胞上皮-間質轉化需要通過GLI1和GLI2的刺猬信號
2. Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway. [J] . Bai CB, Lee JS, Joyner AL Development . 2002,第20期

機譯：Gli2，但不是Gli1，是初始Shh信號傳導和Shh途徑的異位激活所必需的。
3. Targeting the hedgehog transcription factors GLI1 and GLI2 restores sensitivity to vemurafenib-resistant human melanoma cells [J] . FFai?o-Flores, D KAlves-Fernandes, P CPennacchi, Oncogene . 2017,第13期

機譯：靶向刺猬轉錄因子GLI1和GLI2恢復對耐維拉非尼的人黑色素瘤細胞的敏感性
4. Regulation of the Primary Human Trophoblast Cell Secretome by Mechanistic Target of Rapamycin (mTOR) Signaling [C] . Susan T. Weintraub, Frederick Rosario, Sam Pardo, ASMS Conference on Mass Spectrometry and Allied Topics . 2015

機譯：雷帕霉素（MTOR）信號傳導機械靶標調節初級人滋養細胞沉淀
5. Autocrine and Paracrine Signaling Regulates Breast Cancer Stem Cells and Epithelial-Mesenchymal Transition in Inflammatory Breast Cancer [D] . Valeta, Amanda. 2016

機譯：自分泌和旁堿基信號調節炎癥乳腺癌中的乳腺癌干細胞和上皮 - 間充質轉換
6. Targeting the hedgehog transcription factors GLI1 and GLI2 restores sensitivity to vemurafenib-resistant human melanoma cells [O] . F Fai?o-Flores, D K Alves-Fernandes, P C Pennacchi, -1

機譯：靶向刺猬轉錄因子GLI1和GLI2恢復對耐維拉非尼的人黑色素瘤細胞的敏感性
7. Targeting Hedgehog transcription factors GLI1 and GLI2 restores sensitivity to vemurafenib-resistant human melanoma cells [O] . Goding, C, Flores, FF, Alves-Fernandes, DK, 2016

機譯：靶向刺猬轉錄因子GLI1和GLI2恢復對耐維拉非尼的人黑色素瘤細胞的敏感性

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Hedgehog signaling through GLI1 and GLI2 is required for epithelial-mesenchymal transition in human trophoblasts

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