Effect of circovirus vaccination on immune responses, viral load, and growth performance of pigs under field conditions.

機譯：圓環病毒疫苗接種對田間條件下豬的免疫應答，病毒載量和生長性能的影響。

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Vaccination against porcine circovirus type 2 (PCV2) has become a standard practice to improve pig mortality and growth rate in PCV2-affected herds. Unfortunately, there has been little field-based research evaluating factors which affect circovirus vaccination. The focus of this research was on potential vaccination-affecting factors such as age, dosing strategy, pig genetic makeup, and interaction with other vaccines. A total of 6,275 pigs were used to determine factors which affect circovirus vaccination and the effects of vaccination on average daily gain (ADG), immune responses, and viral circulation under field conditions. In the first study evaluating circovirus vaccination effects on PCV2 antibody titer, regardless of age and dose administration protocol, pigs vaccinated with a 2-dose circovirus vaccine had increased (P ≤ 0.008) antibody titers compared with non-vaccinates. In a second study, dosing strategy failed (P = 0.31) to affect antibody titers. However, product and time after vaccination did affect ( P = 0.005) antibody titers. In another 130-d study across the nursery and finishing phases, pigs vaccinated with a 2-dose circovirus vaccine had decreased (P 0.001) serum PCV2 viral load compared with non-vaccinates and ADG of vaccinates was better than non-vaccinates. However, the effect was more pronounced (vaccination-by-genetic interaction, P ≤ 0.05) in Duroc-based compared to Pietrain-based pigs. In a study limited to the nursery phase, vaccination for PCV2 and Mycoplasma hyopneumoniae independently reduced ADG and consumption, but the effect was product-dependent. In a 155-d study across the nursery and finishing phases, vaccination with a 2-dose, 2-vaccine program for PCV2 and Mycoplasma hyopneumoniae decreased (P 0.001) nursery ADG but tended to increase (P = 0.06) finishing ADG compared to a 1-dose, 2-vaccine program, with no difference (P = 0.66) observed between final pig weights. Finally, circovirus vaccination affected PCV2-circulation in high-health research herds but not in a commercial herd where PCV2 DNA was detected in the environment. These results indicate that finishing performance was improved by a 2-dose circovirus vaccine; however, nursery performance was negatively affected by the same product. Circovirus vaccination responses of growth, viral load, and antibody titer were affected by pig genetic makeup, product, and PCV2-exposure status.

機譯：針對2型豬圓環病毒（PCV2）的疫苗接種已成為提高豬死亡率和PCV2感染豬群生長速度的標準方法。不幸的是，很少有基于現場的研究來評估影響圓環病毒疫苗接種的因素。這項研究的重點是影響疫苗接種的潛在因素，例如年齡，劑量策略，豬的遺傳構成以及與其他疫苗的相互作用。共使用6,275頭豬來確定影響圓環病毒疫苗接種的因素以及疫苗接種對田間條件下平均日增重（ADG），免疫反應和病毒循環的影響。在第一項評估圓環病毒疫苗接種對PCV2抗體效價的影響的研究中，無論年齡和劑量給藥方案如何，與未接種疫苗相比，接種2劑量圓環病毒疫苗的豬的抗體效價均升高（P≤0.008）。在第二項研究中，給藥策略未能影響抗體滴度（P = 0.31）。但是，疫苗接種后的產品和時間確實會影響（P = 0.005）抗體效價。在整個育苗期和育苗期的另一項130天研究中，接種了2劑量圓環病毒疫苗的豬與未接種疫苗相比降低了血清PCV2病毒載量（P <0.001），并且接種疫苗的ADG優于未接種疫苗。然而，與基于Pietrain的豬相比，基于Duroc的豬的影響更為明顯（疫苗接種-遺傳相互作用，P≤0.05）。在一項僅限于育苗期的研究中，對PCV2和豬肺炎支原體進行疫苗接種可獨立降低ADG和消耗量，但效果取決于產品。在整個育苗階段和育肥階段的155天研究中，與PCV2和豬肺炎支原體的2劑量，2疫苗接種疫苗相比，育苗ADG減少了（P <0.001），但育成ADG卻增加了（P = 0.06） 1劑2疫苗方案，最終豬體重之間無差異（P = 0.66）。最后，圓環病毒疫苗接種會影響高健康研究人群的PCV2循環，但不會影響在環境中檢測到PCV2 DNA的商業人群。這些結果表明，使用2劑量的圓環病毒疫苗可提高育肥性能。但是，同一種產品對苗圃的性能產生了負面影響。生長，病毒載量和抗體滴度的圓環病毒疫苗接種反應受豬遺傳組成，產品和PCV2暴露狀態的影響。

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Potter, Megan Lynn.;
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Kansas State University.;

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授予單位 Kansas State University.;
學科 Agriculture Animal Pathology.;Health Sciences Immunology.;Biology Veterinary Science.
學位 Ph.D.
年度 2010
頁碼 148 p.
總頁數 148
原文格式 PDF
正文語種 eng
中圖分類
關鍵詞
入庫時間 2022-08-17 11:36:57

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1. Evaluation of a quantitative trait loci for porcine circovirus type 2b viral load on long-term growth performance and nutrient digestibility in inoculated or vaccinated pigs for porcine circovirus type 2b. [J] . van Sambeek D. M., Trenhaile-Grannemann M. D., Miller P. S., Journal of Animal Science . 2017,第Suppla2期

機譯：評價豬胃腸病毒2B型病毒載體的定量性狀基因座對豬循環系統病毒2B型接種或接種豬的長期生長性能和營養消化率。
2. Evaluation of a QTL for porcine circovirus type 2b (PCV2) viral load on growth performance in inoculated and vaccinated pigs for PCV2. [J] . van Sambeek D. M., Tosky E. R., Miller P. S., Journal of Animal Science . 2016,第Suppla2期

機譯：評價豬循環型2B型QTL（PCV2）病毒載體對PCV2接種和疫苗豬生長性能的病毒載量。
3. 309 Evaluation of a QTL for porcine circovirus type 2b (PCV2) viral load on growth performance in inoculated and vaccinated pigs for PCV2. [J] . Burkey?T. E. Journal of animal science . 2016,第supplement2期

機譯：309對豬圓環病毒2b型（PCV2）病毒載量的QTL對PCV2接種和接種豬的生長性能的評估。
4. EFFECT OF SOW VACCINATION AGAINST PORCINE CIRCOVIRUS TYPE 2 (CIRCOVAC~R) IN CONVENTIONAL FARM UNDER HIGH VIRAL LOAD [C] . H. Ishikawa, K. Tokuyama, M. Shiba, Congress ofthe International Pig Veterinary Society . 2008

機譯：高病毒載量播種粉刺疫苗接種對豬胃腸病毒2（CircoVac?R）的影響
5. Effects of porcine circovirus type 2 vaccination, biofuel co-products, and dietary enzymes on finishing pig performance under field conditions. [D] . Jacela, Jay Yanoria. 2009

機譯：豬圓環病毒2型疫苗接種，生物燃料副產品和膳食酶對田間條件下肥育豬性能的影響。
6. Longitudinal comparison of the humoral immune response and viral load of Porcine Circovirus Type 2 in pigs with different vaccination schemes under field conditions [O] . Diana S. Vargas-Bermudez, Andrés Díaz, José Darío Mogollón, -1

機譯：田間條件下采用不同疫苗接種方案的豬2型豬圓環病毒的體液免疫應答和病毒載量的縱向比較
7. Effect of circovirus vaccination on immune responses, viral load, and growth performance of pigs under field conditions [O] . Potter Megan Lynn 100

機譯：圓環病毒疫苗接種對野外條件下豬的免疫反應，病毒載量和生長性能的影響

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Effect of circovirus vaccination on immune responses, viral load, and growth performance of pigs under field conditions.

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